RESEARCH AND EXTENSION
RESEARCH AND EXTENSION
Ongoing Research
Principal Investigators: Dr. Eva Maria C. Cutiongco-de la Paz, Dr. Ian Tabios, Dr. Aloysius Domingo
Duration: 03/2022 to 06/2026
Funding Agency: DOST-PCHRD and CCXDP (USA)
X-linked Dystonia Parkinsonism (XDP) or Lubag is a debilitatingly severe neurodegenerative disease that affects males with maternal ancestry tracing back to the Panay region of the Philippines. We aim to estimate the genetic prevalence of XDP in the Philippines using randomly selected biobanked de-identified residual dried blood spots (DBS) from the Philippine Newborn Screening Program, which provides a nearly complete representation of the population. Our study will serve as reference for further research, clinical guidelines, and public health policymaking. More importantly, a similar workflow for the study of other diseases common to the Filipino population may be developed, tested, and validated in the future.
Principal Investigator: Dr. Ian Tabios
Co-Investigators: Dr. Sheriah de Paz-Silava, Dr. Ourlad Tantengco, Dr. Michelle Diwa
Duration: 10/2024 to 10/2026
Funding Agency: DOST under the VVRP
The gold standard in the diagnosis of genital HPV and HSV-2 infections is the PCR-based detection of viral nucleic acid from physician-collected genital swabs. Although highly accurate, this method involves an invasive and highly uncomfortable sample collection, which has been shown to negatively impact testing uptake. We aim to determine the diagnostic accuracy of molecular testing using self-collected specimens compared to the use of physician-collected genital swabs as reference standard. This project will provide a simplified testing workflow for HPV and HSV-2 that can be easily deployed in public health surveys, even in geographically isolated and disadvantaged areas (GIDA) where access to physicians and cold chain support are limited.
Punching of blood cards
PCR Reagent preparation
Realtime PCR assay
Maintenance of snail aquaria
PCR reagent preparation
Training of laboratory analyst
Public health forum
Malacological survey
Field microscopy
Field interviews
Processing of stool specimens
Animal blood collection
Climacosa, F.M.M., Ornos, E.D.B., Diwa, E.R.S., Guantia, M.G.R., Qureshi, A.P., Gapaz, N.C.L.L., Dacasin, A.B., Asis, J.L.B., Carampel, A.C., Dela Cruz, A.M., Gordovez, F.J.A., Reyes, J.C.B., Tabios, I.K.B., Manalo, R.V.M., Cruz, J.M.C. and Anlacan, V.M.M. (2026) ‘Challenges in community-based recruitment of Alzheimer’s disease cases: Experience of the monitoring drug efficacy through multi-omics research initiative in Alzheimer’s disease (MEMORI-AD) study’, Journal of Alzheimer’s Disease Reports, 10, pp. 1–13.
Boco, S.R., Capidos, C.G., Fornillos, R.J., Sucharitakul, P., Lawley, J.W., Talacay, D., Collins, A.G., Fontanilla, I.K., Comendador, J.E. and Ladiao, F.R. (2025) ‘Molecular signatures reveal intra-species divergence, undetectable by traditional morphology, in the deadly box jellyfish, Chironex yamaguchii (Cubozoa; Chirodropidae) of Western Pacific’, Regional Studies in Marine Science, 78, 104033.
Ge, Y., Liu, H., Ren, N., Qadeer, A., Tabios, I.K., Fontanilla, I.K., Leonardo, L.R., Sripa, B. and Cheng, G. (2025) ‘The global prevalence of and factors associated with parasitic coinfection in people living with viruses: a systematic review and meta-analysis’, Pathogens, 14(6), 534.
Macinas, M., Tantengco, O.A.G., de Paz-Silava, S.L.M., Kammala, A.K., Menon, R., Taylor, B.D.P. and Tabios, I.K.B.T. (2025) ‘Comparative analysis of vaginal inflammatory cytokines among HPV-positive and HPV-negative women in Manila, Philippines’, American Journal of Reproductive Immunology, 94(3), e70148.
Salvo, P.L.M., Torriana, P.A., Kunting, A.C., Fontanilla, I.K., Leonardo, L.R., Mamades-Moendeg, K.J., de Cadiz, A.E., Fornillos, R.J.C., Tantengco, A.Z.G. and Tabios, I.K.B. (2025) ‘Molecular identification of heterophyids in human stool samples from the Philippines’, Parasitology International, 104, 103134.
Tantengco, O.A., Khu, M.E., Riosa, J.M., Go, A.M., Ramos, M.J., de Paz-Silava, S.L. and Tabios, I.K. (2025) ‘Sociodemographic and clinical factors associated with bacterial vaginosis among asymptomatic nonpregnant women in the Philippines’, Sexually Transmitted Diseases, 52(12), pp. 10–97.
Tantengco, O.A.G., Tabios, I.K.B.T., Francisco, A.G., Velayo, C.L., Lintao, R.C.V., Climacosa, F.M.M., Dalmacio, L.M.M., Cando, L.F.T., Perias, G.A.S., Acebes, R.A.N. and de Paz-Silava, S.L.M. (2025) ‘Prevalence and genotype distribution of high-risk human papillomavirus infections among women in selected communities in the Philippines: Results of the DEFEAT HPV study’, Journal of Virus Eradication, 11(1), 100620.
Climacosa, F.M., Anlacan, V.M., Gordovez, F.J., Reyes, J.C., Tabios, I.K., Manalo, R.V., Cruz, J.M., Asis, J.L., Razal, R.B., Abaca, M.J. and Dacasin, A.B. (2024) ‘Monitoring drug Efficacy through Multi-Omics Research initiative in Alzheimer’s Disease (MEMORI-AD): A protocol for a multisite exploratory prospective cohort study’, BMJ Open, 14(11), e078660.
Tabios, I.K., Tantengco, O.A., Limpoco, A.G., Domingo, G.D., Ornos, E.D. and Apostol-Nicodemus, L. (2024) ‘Anxiety, depression, and family dysfunction among COVID-19 patients admitted to hospital and isolation facilities in the Philippines’, SciEnggJ, 17(Supplement), pp. 391–399.
Tenorio, J.C., Tabios, I.K., Inpankaew, T., Ybañez, A.P., Tiwananthagorn, S., Tangkawattana, S. and Suttiprapa, S. (2024) ‘Ancylostoma ceylanicum and other zoonotic canine hookworms: neglected public and animal health risks in the Asia–Pacific region’, Animal Diseases, 4(1), 11.
de Paz-Silava, S.L.M., Tabios, I.K.B., Tantengco, O.A.G., Climacosa, F.M.M., Velayo, C.L., Lintao, R.C.V., Cando, L.F.T., Perias, G.A.S., Idolor, M.I.C., Francisco, A.G., Catral, C.D.M., Chiong, C.M. and Dalmacio, L.M.M. (2023) ‘Determinants of Acquisition, Persistence, and Clearance of Oncogenic Cervical Human Papillomavirus Infection in the Philippines: DEFEAT HPV Study Protocol’, Healthcare, 11(5), 658.
Francisco, A.G., Reyes, J.C., Tabios, I.K., Cruz, C.J., Ang, M.A., Heralde III, F.M., Lacuna, A.R. and de Paz-Silava, S.L. (2023) ‘Seroprevalence of human adenovirus type 5 neutralizing antibodies in the Philippines’, PLOS ONE, 18(12), e0293046.
Manalo, D.L., Bolivar, J.K., Yap, P.R., Gomez, M.R., Saldo, Z.P., Espino, M.J., Dilig, J.E., Fornillos, R.J., Perez, S.A., Baga, R.A., Sunico, L.S., Fontanilla, I.C. and Leonardo, L.R. (2023) ‘From Perpetual Wetness to Soil Chemistry: Factors Favoring Oncomelania hupensis quadrasi Snail Presence’, Tropical Medicine and Infectious Disease, 9(1), 9.
Apostol-Nicodemus, L., Tabios, I.K.B., Limpoco, A.G.O., Domingo, G.D.P. and Tantengco, O.A.G. (2022) ‘Psychosocial Distress among Family Members of COVID-19 Patients Admitted to Hospital and isolation Facilities in the Philippines’, Journal of Clinical Medicine, 11(17), 5236.
Cando, L.F., Perias, G.A., Tantengco, O.A., Dispo, M.D., Ceriales, J.A., Girasol, M.J., Leonardo, L.R. and Tabios, I.K.B. (2022) ‘The Global Prevalence of Schistosoma mansoni, S. japonicum, and S. haematobium in Pregnant Women’, Tropical Medicine and Infectious Disease, 7(11), 354.
Cruz, T.T., Llanes, K.K., Toledo, J.M., Catabay, J.A., Fornillos, R.J., Fontanilla, I.K. and Paller, V.G. (2022) ‘Prevalence and Molecular Characterization of Ascaridoid Parasites of Philippine Decapterus species’, Journal of Nematology, 54(1), pp. 1–12.
Lintao, R.C.V., Cando, L.F.T., Perias, G.A.S., Tantengco, O.A.G., Tabios, I.K.B., Velayo, C.L. and de Paz-Silava, S.L.M. (2022) ‘Current Status of Human Papillomavirus Infection and Cervical Cancer in the Philippines’, Frontiers in Medicine, 9, 929062.
Tabios, I.K.B., Sato, M.O., Tantengco, O.A.G., Fornillos, R.J.C., Kirinoki, M., Sato, M., Rojo, R.D., Fontanilla, I.K.C., Chigusa, Y., Medina, P.M.B., Kikuchi, M. and Leonardo, L.R. (2022a) ‘Circulating microRNAs as biomarkers of hepatic fibrosis in schistosomiasis japonica patients in the Philippines’, Diagnostics, 12(8), 1902.
Tabios, I.K.B., Sato, M.O., Tantengco, O.A.G., Fornillos, R.J.C., Kirinoki, M., Sato, M., Rojo, R.D., Fontanilla, I.K.C., Chigusa, Y., Medina, P.M.B., Kikuchi, M. and Leonardo, L.R. (2022b) ‘Diagnostic Performance of Parasitological, Immunological, Molecular, and Ultrasonographic Tests in Diagnosing Intestinal Schistosomiasis’, Frontiers in Immunology, 13, 899311.
Demonstration of water conservancy combined with schistosomiasis control
Duration: 2023 to 2025; Funding Agency: Asian Development Fund
Identification of high-risk areas for Taenia solium active transmission in the Philippines
Duration: 2021 to 2025; Funding Agency: WHO WPRO
An integrative diagnostic approach in detecting human and animal schistosomiasis in situations of varying levels of prevalence in the Philippines
Duration: 2021 to 2025; Funding Agency: WHO TDR
Characterization of zoonotic trematodes isolated from snail intermediate hosts in the Philippines
Duration: 2023 to 2025; Funding Agency: OVCRD
Demonstrating the genotyping applications in health of rDBS collected by the Philippine Newborn Screening Program using X-linked Dystonia Parkinsonism as disease model
Duration: 2023 to 2023; Funding Agency: NSRI
Seroprevalence of human Adenovirus 5 neutralizing antibodies in an adult population from urban Philippines: Implications on adenoviral vector-based SARS-CoV-2 vaccines
Duration: 2021 to 2023; Funding Agency: DOST
UP TRAINS: University of the Philippines training assistance program to DOH and RITM
Duration: 2021 to 2023; Funding Agency: DOH
Institute of Biology, College of Science
University of the Philippines Diliman
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